Altered task-related decoupling of the rostral anterior cingulate cortex in depression

CA Leonards; BJ Harrison; AJ Jamieson; J Agathos; T Steward; CG Davey

Journal article

Altered task-related decoupling of the rostral anterior cingulate cortex in depression

CA Leonards, BJ Harrison, AJ Jamieson, J Agathos, T Steward, CG Davey

Neuroimage Clinical | ELSEVIER SCI LTD | Published : 2024

DOI: 10.1016/j.nicl.2024.103564

Abstract

Dysfunctional activity of the rostral anterior cingulate cortex (rACC) – an extensively connected hub region of the default mode network – has been broadly linked to cognitive and affective impairments in depression. However, the nature of aberrant task-related rACC suppression in depression is incompletely understood. In this study, we sought to characterize functional connectivity of rACC activity suppression (‘deactivation’) – an essential feature of rACC function – during external task engagement in depression. Specifically, we aimed to explore neural patterns of functional decoupling and coupling with the rACC during its task-driven suppression. We enrolled 81 15- to 25-year-old young p..

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University of Melbourne Researchers

Ben Harrison Author

Alec Jamieson Author

Trevor Steward Author

Chris Davey Author

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Grants

Awarded by Brain and Behavior Research Foundation

Funding Acknowledgements

The trials involved in this study were funded by the Australian National Health and Medical Research Council (NHMRC) project grants (Grant No. 1024570, Youth Depression Alleviation -Combined Treatment trial (to CGD) and sponsored by Orygen, the National Centre of Excellence in Youth Mental Health, without limitations on publication. The study was also supported by the NHMRC project grant (Grant No. 1064643 to BJH) , a NHMRC/Medical Research Future Fund Investigator Grant (Grant No. MRF1193736 (to TS) ) , a Brain & Behavior Research Foundation Young Investigator Grant (to TS) , and a University of Melbourne McKenzie Fellowship (to TS) . CAL, AJJ, and JA were supported by an Australian Government Research Training Program (RTP) Scholarship. The authors report no biomedical financial interests and declare no conflicts of interest.